They found that by using their system to analyze blood samples with unprecedented detail may improve understanding of the physiological effects of exercise and lead to new treatments for cardiovascular disease and diabetes.

“We found new metabolic signatures that clearly distinguish more-fit from less-fit individuals during exercise,” says Gregory Lewis, MD, of the MGH Heart Center, the paper’s lead author. “These results have implications for the development of optimal training programs and improved assessment of cardiovascular fitness, as well as for the development of nutritional supplements to enhance exercise performance.”

The beneficial health effects of exercise – including reducing the risk of heart disease, stroke and type 2 diabetes – are well known, but the biological mechanisms underlying those effects are unclear. Previous investigations of exercise-induced changes in metabolites – biological molecules produced in often-minute quantities – have focused on the few molecules measured by most hospital laboratories. Using a new mass-spectrometry-based system that profiles more than 200 metabolites at a time – developed in collaboration with colleagues from the Broad Institute of Harvard and MIT, led by Clary Clish, PhD – the MGH-based team analyzed blood samples taken from healthy participants before, immediately following, and one hour after exercise stress tests that were approximately 10 minutes long.

Exercise-associated changes were seen in more than 20 metabolites, reflecting processing of sugars, fats and amino acids as fuels as well as the body’s utilization of ATP, the primary source of cellular energy. Several changes involved metabolic pathways not previously associated with exercise, including increases in niacinamide, a vitamin derivative known to enhance insulin release. Another experiment that analyzed samples taken from different vascular locations indicated that most metabolite changes were generated in the exercising muscles, although some appeared to arise throughout the body. In both experiments, several metabolite changes persisted 60 minutes after exercise had ceased.

“Our results have implications for development of both diagnostic testing to track and improve exercise performance and for interventions to reduce the effects of diabetes or heart disease by improving a patient’s metabolic ‘fingerprint’,” explains Robert Gerszten, MD, director of Clinical and Translational Research at the MGH Heart Center, the study’s senior author. “Improving the health of people with cardiovascular disease is our number one goal, but defining which metabolites become deficient and need to be replenished during exercise could also lead to the next generation of sports drinks that can help healthy individuals achieve their best exercise performance.”

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Lead author Renata Micha, a research fellow at the Harvard School of Public Health, said the researchers found no higher risk of heart disease or diabetes among people who ate unprocessed red meat — beef, pork, or lamb.

Micha and colleagues Dariush Mozaffarian, assistant professor in the department of epidemiology and Sarah Wallace, a junior research fellow in the department of epidemiology, reviewed some 1,600 studies. Twenty studies involving more than 1.2 million people from 10 countries and four continents were found relevant for the review.

The review, published in the journal Circulation, found on average, a daily serving of processed meat — about 1-2 slices of deli meats or one hot dog — was linked to 42 percent higher risk of developing heart disease and a 19 percent higher risk of type 2 diabetes.

“Although cause-and-effect cannot be proven by these types of long-term observational studies, all of these studies adjusted for other risk factors, which may have been different between people who were eating more versus less meats,” Mozaffarian said in a statement.

LEF

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The conference panel consisted of 16 members, which included experts in the fields of family medicine, population health, pediatrics, obstetrics and gynecology, health economics, epidemiology, biostatistics, genetic counseling, medical genetics, nursing, health informatics, endocrinology, behavioral science, ethics, health services and outcomes research, and a public representative

They recognized the need for a balanced perspective when assessing a patient’s family medical history. These experts said they were all very aware of the potential for both the benefits and harms of acting upon information obtained from a patient’s family history. If the information is positive, it could be a useful tool for a health care provider to be able to advise a range of healthy lifestyle changes and steps including diet and exercise, refer a patient to a genetic service or other specialists if needed to aid in the care of the patient.

On the other hand, if the family history is not good, a health care provider could activate theoretical harms, such as over-treatment and patient anxiety; so, these situations need be taken into account.

“Given the unprecedented proliferation of genomic information, it is imperative to clarify the role of family history in improving health,” said Panel Chair Dr. Alfred O. Berg, a Professor in the Department of Family Medicine at the University of Washington, Seattle. “Additionally, increased emphasis on personalized medicine and electronic health records creates a fascinating opportunity to maximize the value of this information responsibly.”

The panel experts also recognized that family history does indeed have an important role in the practice of medicine and could definitely motivate some positive lifestyle changes, which should enhance an individual’s empowerment, and influence clinical interventions. They were aware that it is unclear how this information can be gathered effectively and be positively used in the primary care setting for common diseases.

“Additional research is needed to understand how the routine collection of family history will lead to improved health outcomes. To help address these gaps, the panel outlined several research recommendations in three categories: 1) the family health information to be collected, 2) the optimal way to collect and use it, and 3) the outcomes of this tool for diagnosis and engagement with individuals and family members.”

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Well, last I heard, researchers are saying, “stay away” from these kinds of food and eat lots of vegetables, fruits and nuts instead. Down the road as you age, you’ll be glad you did. Why? Fruits, vegetables and nuts actually help to prevent or reverse harmful metabolic processes in your body. That translated means they help to guard the human body from diseases.

Plant-based foods have an ingredient called phytochemicals which are what provide the better health for our physical bodies, including helping to keep us thinner. That in itself is good news and reason to change our diet from our old way of eating.

Someone once told me they eat junk food because it’s cheaper. Well, guess what…no way, that’s just an excuse so he/she can remain a child. They will pay down the road and it will be much more expensive for their medical bills!

As a matter of fact, overweight and obese people tend to eat fewer vegetables, fruit and nuts and instead consume far more saturated fats. They don’t give their bodies the advantages of protective trace minerals and phytochemicals found in natural foods to aid in warding off physical diseases and other problems.

Eating less plant-based foods causes higher levels of oxidative stress and inflammation in the body. This on top of being obese or overweight can and will produce physical problems in due time.
Research has found that oxidative stress and inflammation in our bodies are definitely associated with the onset of obesity, heart disease, diabetes and joint disease.

“Diets low in plant-based foods affect health over the course of a long period of time,” Dr. Vincent, a researcher in FL. explained in a statement to the press. “This is related to annual weight gain, inflammation and oxidative stress. Those are the onset processes of disease that debilitate people later in life.”

“People who are obese need more fruits, vegetables, legumes and wholesome unrefined grains,” Vincent said. “In comparison to a normal-weight person, an obese person is always going to be behind the eight ball because there are so many adverse metabolic processes going on.”

In order to get enough protective phytochemicals daily, the UF researchers concluded that people should try to consume plant-based foods such as leafy greens, fruits, vegetables, nuts and legumes at the start of each meal.

Vincent suggests, “Fill your plate with colorful, low-calorie, varied-texture foods derived from plants first. By slowly eating phytochemical-rich foods such as salads with olive oil or fresh-cut fruits before the actual meal, you will likely reduce the overall portion size, fat content and energy intake. In this way, you’re ensuring that you get the variety of protective, disease-fighting phytochemicals you need and controlling caloric intake.”

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GrassrootsHealth writes: “Breast cancer is a disease so directly related to vitamin D deficiency that a woman’s risk of contracting the disease can be ‘virtually eradicated’ by elevating her vitamin D status to what vitamin D scientists consider to be natural blood levels.”

That’s the message vitamin D pioneer Dr. Cedric Garland delivered in Toronto Tuesday as part of the University of Toronto School of Medicine’s “Diagnosis and Treatment of Vitamin D Deficiency” conference – the largest gathering of vitamin D researchers in North America this year. More than 170 researchers, public health officials and health practitioners gathered at the UT Faculty club for the landmark event.

Dr. Cedric Garland presented this message that headlined a conference in Toronto as part of the University of Toronto School of Medicine’s “Diagnosis and Treatment of Vitamin D Deficiency” conference – the largest gathering of vitamin D researchers in North America this year. At this conference many aspects of the emerging vitamin D research field were reviewed – It’s a booming discipline that has seen more than 3,000 academic papers this calendar year alone. That makes vitamin D by far the most prolific topic in medicine this year, with work connecting it with risk reduction in two dozen forms of cancer, heart disease, multiple scleroses and many other disorders.

Mostly due to Canada’s northerly latitudes and weak sun exposure, as much as 97 percent of Canadians are vitamin D deficient at some point during the year, according to University of Calgary research -. Sunshine is by far the most abundant source of vitamin D (that’s why it’s called ‘The Sunshine Vitamin’) along with other sources such as salmon and fortified milk. Supplementation of vitamin D also helps raise levels for many people as well.

The world’s leading researchers on vitamin D and many other vitamin D supporters – recommend 2,000 IU of vitamin D daily and vitamin D blood levels of 100-150 nanomoles-per-liter as measured by a vitamin D blood test.

Dr. Garland, whose presentation was entitled “Breast Cancer as a Vitamin D Deficiency Disease” presented data showing that raising one’s vitamin D status near those levels decreased breast cancer risk more than 77 percent.

“’The Sunshine Vitamin’ was once thought of only for bone health, helping the body process calcium. But more recent work has shown that all cells in the body have “vitamin D receptors” which help control normal cell growth. Additionally, Garland presented new evidence that low vitamin D status compromises the integrity of calcium-based cellular bonding within tissues, which when eroded allow rogue cancer cells to spread more readily.

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Just plain old ‘fat’ stored in strategic areas of our bodies can affect our overall health. Thus the “whereabouts” of fat in our human body is an important issue for our over-all health. And fat stored around the waistline, even in a slim person, can be dangerous.

I think most of us already know that even in people with a normal, healthy weight level, but are carrying lots of stored fat around their abdomen are also more likely to develop heart disease and some forms of cancer than those individuals with a slimmer waist line.

Studying over 100,000 women of all shapes and sizes, researchers found that the obese were twice as likely to develop asthma as their slimmer counterparts.

They also found that the women who had a large waistline even though they were of normal weight, were 37 per cent more likely to develop the disease.

And what is the reason for this? Well, research suggests that too much fat accumulated around the belly causes chemical reactions in the body which can adversely affect health.

Julie Von Behren, from the Northern California Cancer Centre, one of the co-authors of the study, warned that “abdominal obesity” was rising faster than the traditional measurements.

She added: “All measures of obesity were strongly associated with increased asthma prevalence. Even being modestly overweight was associated with higher asthma prevalence in this population.”

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And, now we have more bad news. The following are excerpts from a recent article that came to my attention:

It was revealed in a recently study that obese people had 8 percent less brain tissue than people with normal weight, and that overweight people had 4 percent less tissue. According to Thompson, who is also a member of UCLA’s Laboratory of Neuro Imaging, this is the first time anyone has established a link between being overweight and having what he describes as “severe brain degeneration.”

“That’s a big loss of tissue and it depletes your cognitive reserves, putting you at much greater risk of Alzheimer’s and other diseases that attack the brain,” said Thompson. “But you can greatly reduce your risk for Alzheimer’s, if you can eat healthily and keep your weight under control.”

“The brains of obese people looked 16 years older than the brains of those who were lean, and in overweight people looked eight years older,” says Thompson.

“It seems that along with increased risk for health problems such as type 2 diabetes and heart disease, obesity is bad for your brain: we have linked it to shrinkage of brain areas that are also targeted by Alzheimer’s,” said Pittsburgh’s Raji. “But that could mean exercising, eating right and keeping weight under control can maintain brain health with aging and potentially lower the risk for Alzheimer’s and other dementias.”

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“Harvard researchers say drinking coffee may help prevent diseases such as: Cancer: Some studies have found coffee drinkers have lower rates of colon and rectal cancers and are 50 percent less likely to get liver cancer than coffee abstainers.”

Coffee may help prevent type 2 Diabetes.
Coffee may help prevent Parkinson’s disease.
Coffee may be a help in Heart disease.
Coffee may help to increase our Life span, decreasing a risk of premature death.
Coffee may cut the risk of chronic hepatitis C disease from progressing.
Coffee may helps prevent cholesterol from being absorbed by the intestines.
Coffee is one of the most commonly ingested drugs worldwide.
Coffee’s caffeine is addictive.
Like anything, experts advise moderation.

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According to Dr. Valentina Kon of Vanderbilt University, oral activated charcoal which has been used by doctors as an emergency treatment for certain types of poisoning may help exert beneficial effects in kidney disease. The product called AST-120.

fta– It was noted that in mice with profoundly reduced renal mass, treatment with AST-120 led to a dramatic decrease in atherosclerosis, even when charcoal treatment was delayed.

Charcoal may help kidney patients fight heart disease — read more

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It’s the damage to the liver caused by drinking too many carbonated drinks or drinking too much fruit juice.

Liver damage is often associated with alcohol abuse. However, new studies have shown that even non-alcoholic drinks with a high sugar content can cause “fatty liver disease” These drinks evidently cause long term liver damage. Hey, no one wants to have to endure a liver transplant resulting from years and years of excess alcohol and sugar/carbonated abuse.

Members of the medical field are suggesting water…good old fresh water as a substitute for soft drinks and over doses of fruit juices.

And just to give you a hint of how to encourage your family to drink fresh water instead, put a water cooler in your kitchen. We always had a water cooler in our house when the children were growing up. They hardly ever drank anything else. They are grown today with their own families and if you go to any one of their houses you won’t see a soda anywhere. You may see wine and other such stuff, but no sodas.

Scientists say that drinking a couple of cans of soda a day can be so harmful that it could increase by five times the risk of developing fatty liver disease. And this kind of liver damage becomes a factor for developing cirrhosis of the liver, diabetes and heart damage if left untreated. And it seems to not make a difference if these drinks are sugar free, low-fat or diet sodas.

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