“”Research to be presented at the Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB), the foremost society for research into all aspects of eating and drinking behavior, finds that the hormone leptin reduces food intake, in part, by activating the hippocampus, an area of the brain that controls learning and memory function. Leptin is a hormone released from fat cells that acts on the brain to inhibit feeding.

Researchers from the University of Pennsylvania found that when leptin was delivered directly to the hippocampus in rats, the animals consumed less food and lost body weight. Leptin delivered to this region of the brain also impaired the ability of the animals to learn about the spatial location of food.

These findings highlight the need for future research aimed at identifying the role of cognitive processes in food intake and body weight control. “Feeding is a complex behavior that is not always driven by hunger or need. An element of our research program is focused on understanding how learning and memory contribute to excessive food intake, and ultimately obesity,” says Dr. Scott Kanoski, lead author. When fat stores are plentiful, humans and animals may be less focused on learning about cues that provide information about food location and availability.

According to Kanoski, “these findings suggest that the brain receives and responds to signals about body energy status, specifically the amount of body fat reserves, and in turn these signals influence what type of environmental cues we learn about. When leptin signaling is impaired, which is common in obesity, cognitive processes that normally would help inhibit or decrease food intake may also be compromised.”"

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They found that by using their system to analyze blood samples with unprecedented detail may improve understanding of the physiological effects of exercise and lead to new treatments for cardiovascular disease and diabetes.

“We found new metabolic signatures that clearly distinguish more-fit from less-fit individuals during exercise,” says Gregory Lewis, MD, of the MGH Heart Center, the paper’s lead author. “These results have implications for the development of optimal training programs and improved assessment of cardiovascular fitness, as well as for the development of nutritional supplements to enhance exercise performance.”

The beneficial health effects of exercise – including reducing the risk of heart disease, stroke and type 2 diabetes – are well known, but the biological mechanisms underlying those effects are unclear. Previous investigations of exercise-induced changes in metabolites – biological molecules produced in often-minute quantities – have focused on the few molecules measured by most hospital laboratories. Using a new mass-spectrometry-based system that profiles more than 200 metabolites at a time – developed in collaboration with colleagues from the Broad Institute of Harvard and MIT, led by Clary Clish, PhD – the MGH-based team analyzed blood samples taken from healthy participants before, immediately following, and one hour after exercise stress tests that were approximately 10 minutes long.

Exercise-associated changes were seen in more than 20 metabolites, reflecting processing of sugars, fats and amino acids as fuels as well as the body’s utilization of ATP, the primary source of cellular energy. Several changes involved metabolic pathways not previously associated with exercise, including increases in niacinamide, a vitamin derivative known to enhance insulin release. Another experiment that analyzed samples taken from different vascular locations indicated that most metabolite changes were generated in the exercising muscles, although some appeared to arise throughout the body. In both experiments, several metabolite changes persisted 60 minutes after exercise had ceased.

“Our results have implications for development of both diagnostic testing to track and improve exercise performance and for interventions to reduce the effects of diabetes or heart disease by improving a patient’s metabolic ‘fingerprint’,” explains Robert Gerszten, MD, director of Clinical and Translational Research at the MGH Heart Center, the study’s senior author. “Improving the health of people with cardiovascular disease is our number one goal, but defining which metabolites become deficient and need to be replenished during exercise could also lead to the next generation of sports drinks that can help healthy individuals achieve their best exercise performance.”

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By Steven Reinberg
HealthDay Reporter

(HealthDay News) — A system that checks medications and doses using bar codes significantly cuts down on hospital drug errors, researchers from Brigham and Women’s Hospital in Boston report.

“We had the opportunity to design and implement a bar code-scanning system to ensure that every patient in the hospital gets the right medication at the right dose at the right time,” said lead researcher Dr. Eric G. Poon, the hospital’s director of clinical informatics.

“After implementing that new system, we found dramatic reductions in errors made during the process of administering medications,” he added. Poon estimates that using this system prevents 90,000 serious errors each year.

The report is published in the May 6 issue of the New England Journal of Medicine.

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The panel recommended that the cardiac resynchronization therapy defibrillator (CRT-D), tested extensively nationwide under the leadership of cardiologist Arthur Moss, M.D., professor of Medicine at the University of Rochester Medical Center, be approved for use in patients with mild heart failure in the United States.

The device under review was developed by Boston Scientific and is already approved to treat patients with severe heart failure. With device approval by the FDA, nearly 4 million more Americans could be candidates for treatment with the CRT-D. The recommendations by its panels are often, but not always, followed by the FDA.

In the major study which tested the device – the MADIT-CRT trial – patients who had a cardiac resynchronization device combined with a defibrillator (CRT-D) implanted had a 34 percent reduction in their risk of death or heart failure compared to patients receiving only an implantable cardioverter defibrillator (ICD). Heart failure alone was reduced by 41 percent in all patients, with a remarkable 63 percent reduction of heart failure in women. The study results were published last year in the New England Journal of Medicine.

This week, Moss presented clinical data from the MADIT-CRT study at a meeting of the FDA’s Circulatory System Devices panel showing that the combination of an implanted cardiac defibrillator, which detects irregular and potentially fatal heart rhythms and shocks the heart back into a normal rhythm, with cardiac resynchronization therapy, which improves the mechanical pumping action of the heart, provides preventive benefit to patients with more mild cardiac disease.

“The panel’s recommended approval of this therapy is great news for a large population of patients in which it could effectively prevent heart failure progression,” said Moss. “The ultimate goal of this new therapy is to not only help patients live longer, but to help them live better.”

The new device combines two functions found in current devices: an ICD, which is designed to prevent sudden cardiac death, and cardiac resynchronization therapy, which works to reduce heart failure and associated symptoms.

About 70 percent of the approximately 5.5 million Americans with some form of heart failure, or 3.9 million people, have milder forms of heart failure known as “Class I” or “Class II,” the forms considered by the FDA in its decision this week.

Copyright © 2010 NewsRx Inc.

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The chemistry of these human bodies is positively affected by activity of the muscles. And that’s why we are becoming exercise addicts. However, this is good because it is important for the body to burn fatty acids as well as other acids, which happens when we exercise. And this is one way we maintain a healthy body.

Now, we can overdo it with too much or too intense activity and that can cause a build-up of lactic acid and other acids in the muscles. How many of us have experienced sore muscles after of day of intensive exercise? It’s because of this acid build up in our muscles.

It is suggested to take a day off between heavier workouts. This gives the muscles a chance to clear out the acid to avoid the negative effects of a workout that’s very intense. Another cure for this soreness is to drink an alkalinizing powder drink on a daily basis.

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A correct pH level affects our mental outlook, metabolism, organs, tissues, cells, molecules, atoms and chromosomes.

It is a known fact that our bodies react to situations that cause stress in our lives. We need to educate ourselves about how stress can affect our body.

I’ve learned that the human body produces acid when it’s under stress. And this can put a strain on the body if stress becomes chronic.

Another problem is that if stress becomes intensified, often we will turn to damaging habits to try to ease the pain and that can actually amplify the problem of acidity in our bodies. Some of these symptoms include smoking, drinking too much alcohol and overeating all the so-called “comfort foods” that are bad for us.

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“The designation pH stands for “potential of hydrogen” and it refers to the measure of alkalinity or acidity of a solution based on the number of hydrogen ions in the liquid. The more hydrogen ions present, the more acidic the solution. The scale is numbered from 0 to 14 and a solution that is neutral measures a 7. A reading below 7 is acidic, and above is alkaline. Many of the body’s fluids including blood, pancreatic juice, bile, saliva and even seminal fluid are alkaline and must remain so for health to prosper. On the other hand, gastric juices secreted in the stomach like hydrochloric acid are highly acidic, measuring in at around a 2 on the pH scale.”

In a future article I’ll explain more on “PH” for us.

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If someone dies during the conflict-active phase of disease, he says, it’s because of energy loss, weight loss, sleep deprivation, and emotional and mental exhaustion. The stress of receiving a cancer diagnosis, or being given a negative prognosis, is often enough to deprive a person of their life-force. Conventional cancer treatments only accelerate the downward spiral.

Dr Hamer operates under the premise that every disease, including cancer, originates from an unexpected shock experience.

The discovery came after Dr. Hamer, the former head internist in the oncology clinic at the University of Munich, Germany, lost his son in an unexpected tragedy, then developed testicular cancer. The diagnosis led him to study the connection between stressful events and disease by investigating the histories of his cancer patients.

He found that, like himself, every one of his patients had gone through a very stressful episode prior to developing cancer, and, upon investigating other diseases found that every disease is controlled from its own specific area in the brain and linked to a very particular, identifiable, “conflict shock.”

Dr. Hamer developed German New Medicine (GNM), which operates under the premise that every disease, including cancer, originates from an unexpected shock experience. If a patient has not undergone any conventional treatments such as chemotherapy or radiotherapy, GNM has a success rate of 95 percent to 98 percent.

GNM is based of five biological laws that apply scientifically to each and every case of disease. They include:
#1: Every disease is caused by a conflict shock that catches an individual completely off guard.
#2: Provided there is a resolution of the conflict, every disease proceeds in two phases, a conflict-active phase and a healing phase.
#3: Ties the findings of the first two laws into the context of embryology and the evolution of man. It illustrates the biological correlation between the psyche, the brain, and the organ from an evolutionary point of view.
#4: Addresses the role of microbes in the context of evolution and in relation to the three germ layers from which our organs originate. Microbes are indispensable to your survival.
#5: Every so-called disease has to be understood as a “meaningful special biological program of nature” created to solve an unexpected biological conflict.

Again, Dr. Hamer believes that a person cannot die of cancer in and of itself.

While trying to publicize his findings, Dr. Hamer has been persecuted and harassed by German and French authorities. He is now living in exile in Spain where he is continuing his fight for official recognition of GNM.

Again, German New Medicine (GNM), developed by Dr. Hamer, operates under the premise that every disease, including cancer, originates from an unexpected shock experience.

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And the scary thing about this is that the medical field doesn’t yet know the danger levels that are involved as a result of this. The long-term effects are unknown, research tells us.

Just another reason to get off our duffs and loose weight…get rid of that fat. It’s killing us in more ways than one!

“You need to get a certain amount of X-rays to go through the body in order to get an informative image, and excess weight impedes that,” explained the study’s lead author, Jacquelyn C. Yanch, a professor at the Massachusetts Institute of Technology in Boston. “And there are very few ways around that problem, other than increasing an overweight patient’s exposure to radiation to improve the image quality.”

“Americans have gotten larger on average over the last half-century, and so as a result, our radiation dosages have gone up,” she added. “Exposure can be sometimes 20, 30, even 40 times as much for an overweight patient as for a lean person. And in general, we’re also getting more exams and more intensive exams.”

“But even so, we don’t actually know the impact of such high doses over time, or whether they’re dangerous, because we simply haven’t tracked the effect,” Yanch said. “So, it’s very important for us to start monitoring this exposure for each individual patient so we can get a handle on it.”

For a more severely overweight or obese person, the needed dosage was up to 40 times greater than for someone of normal weight.

Yanch and her team pointed out, however, that the development of adipose tissue cancer from radiation exposure has not been proven. In fact, she said, the issue is not that the jury is still out but that it has not even begun to deliberate.

“For some procedures, the standard doses are very low, and so even 20 times higher than that is likely still too low to be concerned about,” she noted. “But for some procedures, the doses to a very overweight person will be quite high. Yet the scientific field does not know what this all means. We don’t know if this is anything to be concerned about yet. We have models and prediction, but no real data.”

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Well, research has revealed that it may be possible to extend our lives through a special diet, which would help to fend off the usual diseases of old age. Wow! Give us this diet!

It’s simple…a diet that restricts calories. This diet contains 30 percent fewer calories than usual and has all the normal healthy ingredients. Mice kept on such a diet from birth have been known to live up to 40 percent longer than comparison mice fed normally.

Two studies of rhesus monkeys were begun more than 20 years ago to see if primates responded to caloric restriction the same way as the mice did. Monkeys live an average of 27 years and a maximum of 40, so the experiments required great patience. And now this patience has paid off. (Don’t we read, “Patience is a virtue?”) The researchers at the University of Wisconsin say the monkeys are showing many beneficial signs of caloric restriction, including significantly less diabetes, cancer, and heart and brain disease.

Caloric restriction slowing aging in a primate species is thought to be premature by some critics.
However, the tests show that 37 percent of the monkeys not on the restricted caloric diet so far have died in ways judged to be due to old age, compared with 13 percent of the dieting group.

The researchers said the dieting monkeys were expected to have 10 percent to 20 percent longer lives, based on equivalent studies started in mice at the same age.

The National Institute on Aging is also conducting a study. They have not yet reported on the number of deaths in the dieting and normal monkey groups.” But there are signs that the immune system is holding up better in the dieting group, an official said.”

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