The presence of significant coronary artery disease (S-CAD) is now being able to be detected by testing a patient’s cardiac respiratory stress response (RSR).

These tests have been found not only to be quick but very accurate.
The findings showed patients with S-CAD had a significantly lower cardiac respiratory stress response compared to patients without. These results suggest that RSR is a strong indicator for the disease.

“To determine cardiac respiratory stress response (RSR), Washington Hospital Center researchers used a new innovative respiratory stress test. The test uses a Pulse Oximeter (PPG) to measure blood flow in the finger in response to paced breathing over a 90 second time period. The PPG data are immediately captured and analyzed using a proprietary algorithm that determines the RSR. All findings were confirmed using Quantitative Coronary Angiography (QCA). In comparison to QCA, the test results were highly accurate, with a sensitivity and specificity of 86% and 81%, respectively. No adverse events were reported.”

“It is always challenging to detect significant coronary artery disease in patients at the physician’s office and often required a physical stress test, including nuclear imaging and often cardiac catheterization” said lead investigator Ron Waksman, MD, Associate Director, Division of Cardiology, Washington Hospital Center and professor of medicine (cardiology) at Georgetown University in Washington DC. “The RSR test is simple and fast to perform in a doctor’s office without the need for significant expense and hardship to the patient, and the results of the study support its accuracy to detect significant coronary artery disease. We believe it could be a useful diagnostic option.”

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